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To treat depression first antidepressant imipramine became. Antidepressant imipramine dibenzazepine analogue of chlorpromazine. Chlorpromazine administration in clinical practice was a major advance in the treatment of mental illness. Initially, imipramine was not intended for the treatment of depression. The antidepressant effect of imipramine was discovered in 1957 on the pharmaceutical market in the US antidepressant imipramine was first introduced under the brand name Tofranil. Antidepressant Tofranil is still available for sale in the US market. Tricyclic antidepressants imipramine can be purchased in the United States under the trade names: imipramine hydrochloride; Surmontil; Imipramine pamoate; Tofranil-PM; Trimipramine maleate.
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Effexor XR is horrible. Even if it helps at first, the long term side effects are not worth it. I was on and off effexor XR for 5 years and then took it for two years straight. Those were the worst two years of my life. My boyfriend went through those two years with me. He tells me about things I don’t even remember doing. I gained 57 pounds in two years. If I wasn’t sleeping, I was lying in bed because of the constant flu-like symptoms. Right before I went off the effexor xr, I thought I was going to die. I have never felt so ill. lexapro, paxil, and other anti-depressants that the gyn. had given me to try, before effexor
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To treat depression first antidepressant imipramine became. Antidepressant imipramine dibenzazepine analogue of chlorpromazine. Chlorpromazine administration in clinical practice was a major advance in the treatment of mental illness. Initially, imipramine was not intended for the treatment of depression. The antidepressant effect of imipramine was discovered in 1957 on the pharmaceutical market in the US antidepressant imipramine was first introduced under the brand name Tofranil. Antidepressant Tofranil is still available for sale in the US market. Tricyclic antidepressants imipramine can be purchased in the United States under the trade names: imipramine hydrochloride; Surmontil; Imipramine pamoate; Tofranil-PM; Trimipramine maleate.
Effexor XR is horrible. Even if it helps at first, the long term side effects are not worth it. I was on and off effexor XR for 5 years and then took it for two years straight. Those were the worst two years of my life. My boyfriend went through those two years with me. He tells me about things I don’t even remember doing. I gained 57 pounds in two years. If I wasn’t sleeping, I was lying in bed because of the constant flu-like symptoms. Right before I went off the effexor xr, I thought I was going to die. I have never felt so ill. lexapro, paxil, and other anti-depressants that the gyn. had given me to try, before effexor
Side effects were:
headaches
muscle aches and weakness(still achy)l
no coordination
ringing in ears(still have this)
irritability
paranoia
high cholesterol
racing heart
anxiety
hypoglycemia
problems driving
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severe depression
Nearly all existing antidepressant medications, including Zoloft, Prozac, and Cymbalta, target the serotonin and norepinephrine neurotransmitter systems and take weeks to work
I have been off the effexor for over two years and it has not been easy. The withdrawals were horrible. I am just starting to feel like I can work again. Excercise, homeopathy, accupressure, vitamins, fish oil and eating whole foods has helped. It is nice to have normal emotions and not feel numb or depressed all the time. I have ups and downs, but that is a normal part of life. I would suggest trying prozac or wellbutrin I had the least side effects on these) if you really need something.
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The second antidepressant, introduced in clinical practice was Amitriptyline. Amitriptyline is an antidepressant appeared in the US under the brand name Elavil amitriptyline in 1961, is one of the few tricyclic antidepressants, is not only used for the treatment of depressive symptoms, but also to relieve pain, cupping anxiety and reduction of some symptoms of schizophrenia. Tricyclic antidepressants amitriptyline is also used to reduce the episodes of aggression during aggressive behavior.
My doctor of 5 years suggested that I try Effexor,as she has had no complaints from any of her other patients.I was on the drug for just over 1 year.My max dose was 112mg a day.I found that when I was on the drug AND taking it properly every 24 hours. that the Wellbutrin could just take Effexor’s place. I am pretty sure she was wrong. I’ve been sick the past 3 days. I am also certain this would be worse if my dose was higher like some of the other posters here. Luckily, i only was taking 75mg once daily.
The tricyclic antidepressants (TCAs) are also used for some forms of anxiety, fibromyalgia, and the control of chronic pain. Potential side effects of TCAs are: dry mouth, blurred vision, increased fatigue and sleepiness, weight gain, muscle twitching (tremors), constipation, bladder problems such as urine retention, dizziness, daytime drowsiness, increased heart rate, sexual problems. Learn more about how TCAs help.
But once that 24th hour,25th hour,and so on came around. I felt worse than when I wasn’t on anything.Taking the dose of 75mg or higher,I HAD to take the pills with food or I would be vomiting for hours.I started whiening myself off of the drugs 2 months ago because my doctor told me not to quit cold turky.So like a good girl I went on 112mg a day for 2 weeks.Then I went on 75mg for 2 weeks.Then I went on 37.5mg for 2 weeks.I was finally on my last leg of the journey,37.5mg every other day for 2 weeks.I took my pill on the monday,not to have a pill untill wednesday.
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Well tuesday i felt like crap!!! I took my pill on wednesday,not to have one untill friday.Well I didnt make it that far.I stopped taking Effexor imediatly.There was NO WAY I was going to put that stuff inside my body again.For 9 days after I came off the drug, I could not think,I could not walk more than 10 steps without feeling like I was going to pass out.My mind felt like jello.I had uncontrolable crying fits,that would last for hours.Whats scary is that I have 2 very young children that I take care of every day,and my mind and body could not keep up with my life.There needs to be more warning to patients from medical companies,of side effects when trying to get off this drug .
Doxepin is one of the most well-known tricyclic antidepressants alone. Doxepin antidepressant known under such brands as: Aponal, Adapine, Doxal (Orion), Deptran, Sinquan, Sinequan. Doxepin has first become available for sale under the tradename Aponal (manufacturer: Boehringer-Mannheim, part Roche). Oral tablets and capsules Doxepin successfully used to treat sleep disorders, but Doxepin topical cream indicated for the treatment of dermatological itching Pamelor   nortriptyline hydrochloride
Sinequan  doxepin hydrochloride Surmonti
When I first began using effexor I was very happy with the result. I have Rheumatoid Arthritis and it relieved my pain. But as time went on I realized I was more excitable and where I has always been frugal began spending money on clothing, etc. that I did not need. Plus, my pains began to recur.
It took a year to get off of Effexor and I still have a whirling sound in my head at times. It was an awful withdrawal process. (dizziness, ill feeling, nausea, unsteady gait).
A neurologist put me on BP medication. The headaches were daily and non-stop. The only thing that kept me going was that I was a teacher and I couldn’t miss work, but I could barely function due to the pain. I was eventually placed on oxygenby my family doctor to treat the migraines. I became very frustrated after months of feeling awful and I couldn’t stand having to have the home oxygen therapy. I was a healthy person stuck inside an unhealthy body and I was sick and tired of feeling sick and tired! I slowly took myself off the two medications and increased my Yoga and meditation practice. The headaches stopped when I stopped the medications and my blood presssure dropped back into the normal range!
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During the withdrawal process, I became depressed, angry with people and withdrew. Before, I had been known as even tempered. I lost friends that I had had for years because of my erratic conversations. I was up to 225 mg and then taken down to 75 mg. I have gained 20 lbs which is depressing in itself so I decided to stop taking it on my own. So far the withdrawal symptoms seem to be dizziness.
I do not think a general practicing doctor should have been allowed to distribute this drug. It is definitely a drug that needs to be dispersed by a physician who understands the effects of cognitive altering medication.
With 30 day supply of 150mg, started to alternate to 75mg every other day. So 150mg one day, 75mg the other. After about 2 wks of this began to alternate to 75mg for 2days, 150mg on the third. By the 4th wk, was completely tapered to 75mg.
First effective antidepressant to treat insomnia trimipramine. Antidepressant trimipramine is also known under the trade names: Surmontil, Rhotrimine, Stangyl. Trimipramine uniqueness lies in the fact that it has an antidepressant, anxiolytic, antipsychotic, sedative and analgesic action. Trimipramine similarly Doxepin in the therapeutic spectrum. In addition, trimipramine has a powerful sedative effect, and it is the only effective treatment for insomnia antidepressant that does not disrupt normal sleep architecture. In particular, trimipramine sequence gives no fast and slow sleep phase.
All tricyclic antidepressants almost equally effective in the treatment of depressive states. Thus, the choice of tricyclic antidepressants, depends on several factors. They include: power antidepressant effect, the presence of comorbidities and medications used to treat these diseases.
Therapeutic effect of tricyclic antidepressants may appear several weeks after use. However, the use of tricyclic antidepressants should be continued, even if symptoms disappear doldrums. To avoid the risk of treatment-resistant depression, antidepressant therapy is recommended for 4-6 months.
Long-term use of tricyclic antidepressants is not addictive. However, to reduce the risk of withdrawal, the use of tricyclic antidepressants is to be terminated, gradually reducing the dose for several weeks.
75mg 2 wks total, then did the same tapering with 75mg and 37.5mg.

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